睡眠和学习记忆的神经环路以及分子机制，以及睡眠障碍和认知衰退诊疗干预的新靶点和策略。

刘畅，博士生导师，深圳理工大学教研副教授/科研正教授/中国科学院深圳先进技术研究院研究员。入选中国科学院重点人才计划（百人计划）、深圳市海外高层次人才。研究聚焦于睡眠调控的神经机制，并围绕睡眠和记忆的神经整合环路机制以及神经调控干预睡眠障碍和认知衰退的新靶点和策略展开系统研究。已发表SCI论文20余篇，其中第一/通讯作者工作发表在包含Nature、Current Biology、Journal of Neuroscience、eLife、CNS Neuroscience & Therapeutics等。

学习经历

2007.09–2012.07, 中国科学院昆明动物研究所/德国马克思-普朗克神经生物学研究所  联合培养博士（导师：马原野研究员，Hiromu Tanimoto教授）

1999.09–2003.07, 河北师范大学  学士

工作经历

2025.6-至今，生命健康学院生物学系，教研副教授/科研正教授

2019.01-至今, 中国科学院深圳先进技术研究院, 研究员

2012.07-2019.01, 美国布兰迪斯大学，博士后（导师：Leslie C. Griffith教授）

2004.06-2007.08, 中国科学院昆明动物研究所，研究实习员

2003.06-2004.06, 石家庄二中，高中教师

国际影响力

2019-至今 担任《Neuroscience Bulletin》杂志青年编委

国际学术会议（大会报告）

（1）2025.06.15-20 Workshop on Neural Circuits and Behavior of Drosophila, Orthodox Academy of Crete, Kolymbari. Oral presentation. Title: “The EB orchestrates sleep structure through a dynamic homeostatic local circuit”.

（2）2024.09.09-13 2024 Cold Spring Harbor Asia Conference: Functions and Regulation of Sleep, Suzhou, China. Oral presentation. Title: “A microcircuit for linking sleep and memory in Drosophila”.

（3）2024.02.27-03.01 Aisa Pacific Drosophila Neuroscience Conference, Tokyo. Oral presentation. Title: “A microcircuit integrates sleep and memory consolidation”.

（4）2023.10.11-12 Circadian Rhythms in Sleep, Physiology & Medicine, Chongqing, China. Oral presentation. Title: “Local circuits in regulation of frequent light/dark cycle induced sleep disturbance”.

（5）2023.08.23-27 The 3rd Jiujiang International Drosophila Conference, Jiujiang, China. Oral presentation. Title: “Regulation of sleep maintenance by a local circuit within the ellipsoid body”.

（6）2023.05.28-06.03 Workshop on Neural Circuits and Behavior of Drosophila, Orthodox Academy of Crete, Kolymbari. Oral presentation. Title: “Regulation of sleep maintenance by a local circuit within the EB”.

（7）2021.07.14-19 5th Asian Forum on Chronobiology, Kaifeng. Oral presentation. Title: “A Local Circuit within the Ellipsoid Body Regulates Sleep Structure”.

主持项目

（1）国家自然科学基金专项项目，5-HT7在微觉醒异常调控引发睡眠呼吸障碍中的神经机制，2024/01-2026/12，100万，在研，主持

（2）国家自然科学基金面上项目，奖赏性多巴胺环路共调控记忆巩固和睡眠结构的神经机制，2024/01-2027/12，50万，在研，主持

（3）国家自然科学基金面上项目，椭球体调控睡眠结构的神经环路机制，2021/01-2024/12，58万，主持 （已结题）

（4）中国科学院率先计划引才项目（B类），2022/01-2024/12，500万，主持（已结题）

（5）广东省基础与应用基础研究基金自然科学基金面上项目，失眠与记忆损伤共调控的神经环路机制，2024/01-2026/12，15万，在研，主持

1. Yan L, Wu L, Wiggin TD, Su X, Yan W, Li H, Li L, Lu Z, Li Y, Meng Z, Guo F, Li F^*, Griffith LC^*,Liu C^*. Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep. eLife, 2025, 14: RP104862.

2. Ge D^#, Han C^#, Liu C^*, Meng Z^*. Neural oscillations in the somatosensory and motor cortex distinguish dexmedetomidine-induced anesthesia and sleep in rats. CNS Neuroscience & Therapeutics, 2025.31(2):e70262.

3. Zhang S, Wang L, Yi S, Tsai Y, Cheng Y-H, Lin Y-T, Lin C-C, Lee Y-H, Wang H, Li S, Wang R, Liu Y, Yan W, Liu C, He K-W, Ho MS^*. Drosophila aux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to SNCA/α-synuclein degradation. Autophagy, 2025 Jan 29: 1-20.

4. Yan W^#, Li Z^#, Lin Z, Ji S, Tse WKF, Meng Z, Liu C^*, Li L^*. Microplastics exposure disturbed sleep structure, reduces the lifespan and ovary size of Drosophila melanogaster. Zoological Research, 2024, 45(4):805-820 (cover paper)

5. Wu L, Liu C^*. Integrated neural circuits of sleep and memory regulation in Drosophila. Current Opinion in Insect Science, 2023, 59:101105.

6. Wang H^#, Chen G^#, Ahn EH, Xia Y, Kang SS, Liu X, Liu C, Han M-H, Chen S^*, Ye K^*. C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-Synuclein in the gut and brain. npj Parkinson's Disease, 2023, 9(1):1.

7. Yan W, Lin H, Yu J, Wiggin TD, Wu L, Meng Z, Liu C^*, Griffith LC^*. Subtype-specific roles of ellipsoid body ring neurons in sleep regulation in Drosophila. Journal of Neuroscience, 2023, 43(5):764–786 (cover paper)

8. Meng Z^*, Li Q, Ma Y, Liu C^*. Transcranial current stimulation of the frontal-parietal-temporal brain areas reduces cigarette consumption in abstinent heroin users. Journal of Psychiatric Research, 2022, 152:321-325.

9. Li Q, Fu Y, Liu C^*, Meng Z^*. Transcranial direct current stimulation of the dorsolateral prefrontal cortex for treatment of neuropsychiatric disorders. Frontiers in Behavioral Neuroscience, 2022, 16:893955

10. Jin X, Tian Y, Zhang ZC, Gu P, Liu C, Han J^*. A subset of DN1p neurons integrates thermosensory inputs to promote wakefulness via CNMa signaling. Current Biology, 2021, 24;31(10):2075-2087.e6.

11. Wiggin TD, Goodwin PR, Donelson NC, Liu C, Trinh K, Sanyal S, Griffith LC^*. Covert sleep-related biological processes are revealed by probabilistic analysis in Drosophila. PNAS, 2020, 117(18)10024-10034

12. Liu C^*, Meng Z^#, Wiggin TD^#, Yu J, Guo F, Reed M, Zhang Y, Rosbash M, Griffith LC^*. A serotonin-modulated circuit controls sleep architecture to regulate cognitive function independent of total sleep in Drosophila. Current Biology, 2019, 29(21):3635-3646.

13. Liu C, Plaçais P-Y, Yamagata N, Pfeiffer BD, Aso Y, Friedrich AB, Siwanowicz I, Rubin GM, Préat T, Tanimoto H^*. A subset of dopamine neurons signals reward for odour memory in Drosophila. Nature, 2012, 488(7412):512-6