灵长类大脑高级认知功能神经基础及调控机制

戴辑，博士，中国科学院深圳先进技术研究院研究员，博士生导师。深圳市灵长类转化医学工程研究中心主任，深圳市蛇口育才教育集团龙珠学校“科学副校长”。入选中国科学院青年创新促进会、深圳市海外高层次人才、鹏城优才（金卡）。曾获2023年度“中国生命科学十大进展”、“中国神经科学重大进展”、“深圳十大科技创新”等奖项。担任中国实验动物学会灵长类实验动物专委会委员、中国生物化学与分子生物学会衰老与退行病专委会委员，担任The Innovation、Zoological Research编委，Innovation, Nature Com., Nat. Sci. Rev等期刊审稿人。

戴辑主要研究大脑高级认知功能神经基础及调控机制，并基于非人灵长类动物构建疾病模型、开发新式诊疗策略。已在Cell, Nature, The Innovation, National Science Review, Advanced Science等著名学术期刊上发表论文40余篇，单篇最高被引1700余次，并被《人民日报》、“新华社”、“央视新闻”、《中国青年报》、《参考消息》等国家媒体报道。

学习经历

2003.9–2010.1, 中国科学院生物物理所, 生物物理学, 博士

1999.9–2003.6, 南京大学, 生物物理学, 学士

工作经历

2017.10-至今, 中国科学院深圳先进技术研究院, 历任副研究员，研究员

2014.10-2017.9, 中国科学院, 心理研究所, 副研究员

2010.9-2014.9, Brown University, Department of Neuroscience, Postdoc fellow

国际影响力

受邀参加有近百年历史的Gordon Research Conference并做报告；

担任The Innovation青年编委、Zoological Research编委；

所获荣誉

2023年度“中国生命科学十大进展”；

2023年度“中国神经科学重大进展”；

科研成果

1. 国家自然科学基金面上项目，32571221，多模态神经生理解析猕猴丘脑-皮层环路动态意识重建机制，2026.01-2029.12，50万元，主持；

2. 国家重点研发计划，生物与信息融合（BT与IT融合）重点专项，2024YFF1206400，多模态自反馈智能驱动神经监测与调控系统，2024.12-2027.11, 1800万，骨干；

3. 国家自然科学基金面上项目，32371066，猕猴下丘脑亚区介导的体温调控新策略研究，2024.01-2027.12，50万元，主持；

4. 深圳市战略性新兴产业扶持计划，XMHT20220104005, 深圳市灵长类转化医学工程研究中心组建项目，2021.10-2025.9，500万元，主持。

Five feature articles：

1. Yefei Chen^#, Zexuan Hong^#, Jingyi Wang, Kunlin Liu, Jing Liu, Jianbang Lin, Shijing Feng, Tianhui Zhang, Liang Shan, Taian Liu, Pinyue Guo, Yunping Lin, Tian Li, Qian Chen, Xiaodan Jiang, Anan Li, Xiang Li, Yuantao Li, Jonathan Wilde, Jin Bao^*, Ji Dai^*, and Zhonghua Lu^*. “Circuit-Specific Gene Therapy Reverses Core Symptoms in a Primate Parkinson’s Disease Model”, Cell, 2023, 186 (24): 5394-5410.e18. Doi: 10.1016/j.cell.2023.10.004.

2. Li Wang^#, Bo Zhang^#, Xiqian Lu, Ruidi Wang, Jian Ma, Yujie Chen, Yuan Zhou, Ji Dai^*, Yi Jiang^*. “Genetic and Neuronal Basis for Facial Emotion Perception in Humans and Macaques”, National Science Review, 2024 11(11), nwae381. Doi: 10.1093/nsr/nwae381.

3. Zhiting Zhang^#, Liang Shan^#, Yuyin Wang^#, Wenfang Li, Minqing Jiang, Feng Liang, Shijing Feng, Zhonghua Lu, Hong Wang^*, Ji Dai^*. “Primate Preoptic Neurons Drive Hypothermia and Cold Defense”. The Innovation, 2023, 4:100358. Doi: 10.1016/j.xinn.2022.100358.

4. Liang Shan^#,*, Hui Huang^#, Zhiting Zhang, Yuyin Wang, Fei Gu, Mingwei Lu, Wen Zhou, Yi Jiang^*, Ji Dai^*, “Mapping the Emergence of Visual Consciousness in the Human Brain via Brain-wide Intracranial Electrophysiology”, The Innovation, 2022, 3:100243. Doi: 10.1016/j.xinn.2022.100243.

5. Xinhe Liu, Zhiting Zhang, Lu Gan, Panke Yu, Ji Dai^*. “Medium Spiny Neurons Mediate Timing Perception in Coordination with Prefrontal Neurons in Primates”, Advanced Science, 2025, 12:2412963, Doi: 10.1002/advs.202412963.

Other Peer-reviewed publications:

6. Wu, Z.^#, Wang, Y.^#, Chen, W.W.^#, Sun H.^#, Chen X.^#, et al., “Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution”, Cell, 2025, 188(8): 2159-2174. doi: 10.1016/j.cell.2025.02.007.

7. Yueqi Wang, Xinhe Liu, Zhiting Zhang, Panke Yu, Ming Yin^*, Ji Dai^*. “Mapping neuronal dynamics in the Thalamus underlying consciousness transition in macaques”, The Innovation Life, 2025, 3:100152.

8. Ling Li, Zhiting Zhang, Xinhe Liu, Mengni Zhou, Shengling Wen^*, Ji Dai^*. “TAK-653 Reverses Core Depressive Symptoms in Chronic Stress-Induced Monkey Model”, Biomedicines, 2025, 13(6):1389. Doi:10.3390/biomedicines13061389.

9. Siyuan Bu^#, Qingyun Wang^#, Gaojia Zhang, Zhiting Zhang, Ji Dai^*, Zhijun Zhang^*. “Inflammation molecular network alterations in a depressive-like primate model”, Journal of Affective Disorders, 2025, 379:410-420.

10. Lu Gan, Zhilin Zhang, Zhiting Zhang, Jinglong Wu^*, Ji Dai^*, Shintaro Funahashi^*.  “What Task Feature Determines the Dominant Task in Dual-Task Conditions?”, eNeuro, 2025, ENEURO.0542-24.2025. doi: 10.1523/ENEURO.0542-24.2025

11. Xinhe Liu, Zhiting Zhang, Ji Dai^*. “Evaluating Pupillometry as a Tool for Assessing Facial and Emotional Processing in Nonhuman Primates”, Applied Science, 2025, 15(6):3022. doi:10.3390/app15063022

12. Ji Dai^#, Huiyu Xu^#, Tao Chen^#, et al., “Artificial intelligence for medicine 2025: Navigating the endless frontier”, The Innovation Medicine, 2025, 3: 100120.

13. Haijun Wang^#, Ji Dai^#, Yuanzheng Cui, Peijun Zhang, Fang Wang^*, Buxing Han^*, Erik Jeppesen. “Shaping the future of academic conferences”, The Innovation, 2025, 6:100738. Doi: 10.1016/j.xinn.2024.100738.

14. Ling Li, Shenglin Wen^*, Ji Dai^*. “The Current State and Future Outlook of PET Tracers for AMPA Receptors”, Neuroscience Bulletin, 2025, 41(3):531-535. Doi: 10.1007/s12264-024-01332-w.

15. Ming Luo^*, Wenyu Yang, Long Bai, et al. “Artificial intelligence for life sciences: A comprehensive guide and future trends”, The Innovation Life, 2024, 2:100105.

16. Zhiting Zhang, Ji Dai^*. “Fully implantable wireless brain-computer interface for humans: Advancing toward the future”, The Innovation, 2024, 5:100595.

17. Yefei Chen^#, Jingyi Wang^#, Jing Liu^#, Jianbang Lin, Yunping Lin, Jinyao Nie, Qi Yue, Chunshan Deng, Xiaofei Qi, Yuantao Li, Ji Dai^*, Zhonghua Lu^*. “A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys”, Neuroscience Bulletin, 2024, 40(1):90-102.

18. Ji Dai^*. “Pursue the nature of science: Advocate for a better research environment”, The Innovation, 2024, 5:100686.

19. Tiantian Li^#, Tao Huang^#, Ning Xiao^#, Ji Dai^*. “Innovative medicine and health management: A special session of The Innovation Conference 2024”, The Innovation Medicine, 2024, 2:100088.

20. Xiayi Feng, Ding Gao, Juan Zhou, Zhu Gui, Aoling Cai, Jie Wang, Ji Dai, Yipeng Jing, Junchao Qian, Zongqiang Cui, Lanxiang Li, Yue You, Luyi Tian, Xian-En Zhang, Dong Men. “Viral capsid-mediated efficient cell labeling of micron-sized magnetic particles for highly sensitive long-term in vivo tumor cells MRI tracking”. Chemical Engineering Journal, 2024, 498: 155830.

21. Li M^#, Guan M^#, Lin J^#, Zhu K^#, Zhu J, Guo M, Li Y, Chen Y, Chen Y, Zou Y, Wu D, Xu J, Yi W, Fan Y, Ma S, Chen Y, Xu J, Yang L, Dai J, Ye T^*, Lu Z^*, Chen Y^*. “Early blood immune molecular alterations in cynomolgus monkeys with a PSEN1 mutation causing familial Alzheimer's disease”, Alzheimer's & Dementia, 2024, 20(8):5492-5510. doi: 10.1002/alz.14046.

22. Jiao J^#, Xu D^#, Kong Y^#*, Cao Y^#, Wang L, Hong Y, Li L, Gao C, Liu J, Zhang G, Zhou J, Dai J, Lu Z, Liu Y, Wang Y^*, Zhang Z^*. “circFKBP8(5S,6)-encoded protein as a novel endogenous regulator in major depressive disorder by inhibiting glucocorticoid receptor nucleus translocation”, Science Bulletin, 2024, 69(24):3826-3831. doi: 10.1016/j.scib.2024.06.021.

23. Gaojia Zhang^#, Ling Li^#, Yan Kong^#,*, Dandan Xu, Yu Bao, Zhiting Zhang, Zhixiang Liao, Jiao Jiao, Dandan Fan, Xiaojing Long, Ji Dai, Chunming Xie, Zhiqiang Meng^*, Zhijun Zhang^*. “Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder”, Genes & Disease, 2024, 11(2):1009-1021.

24. Liang Shan^#, Liu Yuan^#, Bo Zhang^#, Jian Ma, Xiao Xu, Fei Gu, Yi Jiang^*, Ji Dai^*. “Neural Integration of Audiovisual Sensory Inputs in Macaque Amygdala and Adjacent Regions”, Neuroscience Bulletin, 2023, 39(12):1749−1761. (Cover article)

25. Jingyi Wang^#, Jianbang Lin^#, Yefei Chen^#, Jing Liu, Qiongping Zheng, Mao Deng, Ruiqi Wang, Yujing Zhang, Shijing Feng, Zhenyan Xu, Weiyi Ye, Yu Hu, Jiamei Duan, Yunping Lin, Ji Dai, Yu Chen, Yuantao Li, Tao Luo, Qian Chen^*, and Zhonghua Lu^*. “An Ultra-Compact Promoter Drives Widespread Neuronal Expression in Mouse and Monkey Brains”, Cell Reports, 2023, 42:113348.

26. Panke Yu^#, Zhiting Zhang#, Yuyin Wang, Ji Dai^*. “Protocol for MRI-guided virus injection in macaque deep brain regions”, STAR Protocols, 2023, 4:102768.

27. Chunshan Deng, Xiaojian Li, Ji Dai^*. “Challenges for translating implantable brain-computer interface to medical device”, The Innovation Medicine, 2023, 1:100040.

28. Xinhe Liu, Lu Gan, Zhiting Zhang, Panke Yu, Ji Dai^*. “Probing the Processing of Facial Expression via Time Perception and Eye Tracking in Monkeys”, Zoological Research, 2023, 44(5):882-893.

29. Ji Dai^*, Xin Cao, Yong Han, Tianbin Song, Yuming Guo, Jie Qiao. “The Innovation Medicine: An international journal of medical science”, The Innovation Medicine, 2023, 1:100001.

30. Ji Dai^*, “Launching from Earth”, The Innovation, 2023, 4:100430.

31. Ying Zhang^#*, Dheeraj Roy^#*, Yi Zhu, Yefei Chen, Tomomi Aida, Yuanyuan Hou, Chenjie Shen, Nicholas Lea, Margaret Schroeder, Keith Skaggs, Heather Sullivan, Kyle Fischer, Edward Callaway, Ian Wickersham, Ji Dai, Xiao-Ming Li, Zhonghua Lu, Guoping Feng*. “Targeting thalamic circuits rescues motor and mood deficits in PD mice”, Nature, 2022, 607: 321-329.

32. Lu Gan, Jinglong Wu, Ji Dai^*, Shintaro Funahashi^*. “The Mechanism for Allocating Limited Working Memory Resources in Multitasking”, Neuroscience Bulletin, 2022, 38(7):829-833.

33. Jiani Chen, Liang Shan, Ji Dai^*. “Distinct Recovery Process of Consciousness and Cognition after Anesthesia”, Neuroscience Bulletin, 2022, 38(1): 110-112.

34. Yongjun Xu, Qi Wang, Zhulin An, et al., “Artificial Intelligence: A Powerful Paradigm for Scientific Research”. The Innovation, 2021, 2:100179.

35. Ji Dai^*. “Gaining a Better Understanding of Nonhuman Primate Research”, Science Bulletin, 2021, 66(15):1499-1501.

36. Yuxuan Yao, Ji Dai^*. “Naturally Occurring Parkinson’s Disease Raises the Need for Nonhuman Primate in Neurodegenerative Diseases Research”, Neuroscience Bulletin, 2021, 37(8):1267-1269.

37. Tremblay S, Acker L, Afraz A, et al., “An Open Resource for Non-human Primate Optogenetics”. Neuron. 2020, 108(6):1075-1090.e6.

38. Chunshan Deng, Hong Yuan, Ji Dai^*. “Behavioral Manipulation by Optogenetics in the Nonhuman Primate”, The Neuroscientist, 2018, 24(5): 526-539.

39. Ji Dai, Yi Wang. “Contrast coding in the primary visual cortex depends on temporal contexts”, European Journal of Neuroscience. 2018, 47(8): 947-58.

40. Bo Zhang, Ji Dai^*, Tao Zhang. “NeoAnalysis: A Python-Based Toolbox for Quick Electrophysiological Data Processing and Analysis”. Biomedical Engineering Online. 2017, 16:129.

41. Ji Dai^*, Tao Zhang. “The progress of optogenetic studies in nonhuman primates”, Progress in Biochemistry and Biophysics, 2016, 43(4): 354-360.

42. Ji Dai, Ilker Ozden, Daniel I. Brooks, Fabien Wagner, Travis May, Naubahar Agha, Benjamin Brush, David Borton, Arto V. Nurmikko, David L. Sheinberg “Modified toolbox for optogenetics in the nonhuman primate”, Neurophotonics, 2015, 2(3), 031202.

43. Ji Dai, Daniel I. Brooks, David L. Sheinberg. “Optogenetic and electrical microstimulation systematically bias visuospatial choice in primates”. Current Biology, 2014 Jan 6;24(1):63-9.

44. Ji Dai and Yi Wang. “Representation of Surface Luminance and Contrast in Primary Visual Cortex”, Cerebral Cortex. 2012, 22(4):776-87.