1. 神经环路病毒示踪新技术新工具开发

2. 溶瘤病毒药物研制及监管评价

3. 肿瘤-神经系统互作神经网络机制

王华东，生命健康学院副教授，深圳先进院脑所副研究员，深圳市高层次人才。国家药品监督管理局细胞和基因治疗药物技术研究与评价重点实验室、广东省药监局病毒制剂质控技术重点实验室、深圳市生物医药病毒载体重点实验室核心骨干。申请发明专利20余项，已获授权5项。主持国家基金委青年基金、面上项目，广东省、深圳市面上/重点项目等，作为核心骨干参与科技创新2030“脑科学与类脑研究”重大项目、国家重点研发计划、中科院战略先导专项、973项目等。在Nature，PNAS，Cell research，Cell Stem Cell，Emerging microbes & infections等杂志发表/合作发表SCI论文30余篇。任Nature出版集团旗下《Scientific Reports》编委，深圳市细胞和基因产品检测评价专委会常务委员。

学习经历

2008-09至2012-06，中国科学院大学，博士

2004-09至2007-06，湖南师范大学，硕士

2000-09至2004-06，河南师范大学，学士

工作经历

2021-01至今，深圳理工大学，生命健康学院，特聘副教授

2019-11至今，中国科学院深圳先进技术研究院，副研究员

2016-07至2019-10，中国科学院精密测量科学与技术创新研究院，副研究员

2013-09至2016-05，中国科学院精密测量科学与技术创新研究院，博士后

国际影响力

2024年至今，Scientific Reports，编委

科研成果

主持国家基金委青年基金、面上项目，广东省、深圳市面上/重点项目等，作为核心骨干参与科技创新2030“脑科学与类脑研究”重大项目、国家重点研发计划、中科院战略先导专项、973项目等。在Nature，PNAS，Cell research，Cell Stem Cell，Emerging microbes & infections等杂志发表/合作发表SCI论文30余篇。任Nature出版集团旗下《Scientific Reports》编委，深圳市细胞和基因产品检测评价专委会常务委员。申请发明专利20余项，已获授权5项，部分已产业化。

1. Yusha Sun^#, Xin Wang^#, Daniel Zhang, Zhijian Zhang, Janardhan Bhattarai, Yingqi Wang, Kristen Park, Weifan Dong, Yun-Fen Hung, Qian Yang, Feng Zhang, Keerthi Rajamani, Shang Mu, Benjamin Kennedy, Yan Hong, Jamie Galanaugh, Abhijeet Sambangi, Sang Hoon Kim, Garrett Wheeler, Tiago Gonçalves, Qing Wang, Daniel Geschwind, Riki Kawaguchi, Angela Viaene, Ingo Helbig, Sudha Kessler, Ahmet Hoke, Huadong Wang, Fuqiang Xu, Zev Binder, H Isaac Chen, Emily Ling-Lin Pai, Sara Stone, MacLean Nasrallah, Kimberly Christian, Marc Fuccillo, Nicolas Toni, Zhuhao Wu, Hwai-Jong Cheng, Donald O'Rourke, Minghong Ma, Guo-Li Ming^*, Hongjun Song^*. Brain-wide neuronal circuit connectome of human glioblastoma. Nature. 2025 Jan 16. doi: 10.1038/s41586-025-08634-7.

2. Basma Eid Abdullah Ghorab^#, Tongtan Liu, Min Ying, Ping Wang, Meirong Qin, Jiayong Xing, Huadong Wang^*, Fuqiang Xu^*. Advances in the Drug Development and Quality Evaluation Principles of Oncolytic Herpes Simplex Virus. Viruses. 2025 Apr 18;17(4):581

3. Yan Chen^#, Yuran Song^#, Huadong Wang^#, Yiyun Zhang, Xinyu Hu, Kaikai Wang, Yingjin Lu, Zoutao Zhang, Shuai Li, Anan Li, Lan Bao, Fuqiang Xu, Changlin Li^*, Xu Zhang^*. Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2118501119.

4. Min Ying^#, Huadong Wang^#,*, Tongtan Liu, Zengpeng Han, Kunzhang Lin, Qing Shi, Ning Zheng, Tao Ye, Huinan Gong, Fuqiang Xu^*. CLEAR Strategy Inhibited HSV Proliferation Using Viral Vectors Delivered CRISPR-Cas9. Pathogens. 2023 Jun 7;12(6):814.

5. Bing Cai^#, Dan Wu^#, Hong Xie^#, Yan Chen, Huadong Wang, Sen Jin, Yuran Song, Anan Li, Shiqi Huang, Sashuang Wang, Yingjin Lu, Lan Bao, Fuqiang Xu, Hui Gong, Changlin Li^*, Xu Zhang^*. A direct spino-cortical circuit bypassing the thalamus modulates nociception. Cell Research. 2023 Oct;33(10):775-789.

6. Jin Zhang, Quan Xu, Yifang Zhang, Mohamed F Foda, Kai Cai, Qing Liu, Fan Jia, Huadong Wang, Fuqiang Xu, Heyou Han, Huageng Liang. Natural bioactive lysosomes extracted from multiple cells for tumor therapy. Biomaterials. 2024:304:122430.

7. Dennis Jgamadze, James Lim, Zhijian Zhang, James Germi, Kobina Mensah-Brown, Chris Adam, Jiahe Ben Gu, Paul Harary, Rachel Blue, Marissa Fu, Fadi Jacob; Xuyu Qian, Kimberly Gagnon, Matthew Sergison, Oceane Fruchet, Imon Rahaman, Huadong Wang, Fuqiang Xu, Rui Xiao, Diego Contreras, John A. Wolf, Hongjun Song, Guo-li Ming, H. Isaac Chen. Structural and functional integration of human forebrain organoids with the adult rat visual system. Cell Stem Cell. 2023 Feb 2;30(2):137-152.e7.

8. Xin Liu^#, Huadong Wang^#, Lin Ma, Min Ying, Qing Liu, Heng Chang, Sen Jin, Fang Yang, Xutao Zhu, Xinghuai Sun^*, Fuqiang Xu^*, Haixia Liu^*. Construction of a mouse model of Posner-Schlossman syndrome by anterior chamber infection with cytomegalovirus. Exp Eye Res. 2022 May;218:109009.

9. Qing Liu, Yang Wu, Huadong Wang, Fan Jia, Fuqiang Xu*. Viral Tools for Neural Circuit Tracing. Neurosci Bull. 2022 Dec;38(12):1508-1518.

10. Peng Su^#, Min Ying^#, Zengpeng Han, Jinjin Xia, Sen Jin, Yingli Li, ^{Huadong Wang*,} Fuqiang Xu^*. High-brightness anterograde transneuronal HSV1 H129 tracer modified using a Trojan horse-like strategy. Molecular brain. 2020; 13(1): 5.