Associate Professor at Shenzhen University of Advanced Technology (SUAT, Preparatory) and Drug and Medical Device Evaluation Expert at the Shenzhen Market Supervision Administration.Myresearch focuses on the molecular mechanisms and intervention strategies for neuropsychiatric disorders, particularly neurodegenerative diseases and the neural mechanisms of drug addiction, as well as the development of novel therapeutic approaches.Ihaveled or participated in multiple national, Guangdong provincial, and Shenzhen municipal research projects.Ihavealso published several first- and corresponding-author papers in Nature Communications, Journal of Neuroscience, and Neuroscience Bulletin.

Investigating the pathogenesis and intervention strategies of neuropsychiatric disorders using cutting-edge techniques such as metabolomics, single-cell sequencing, two-photon calcium imaging, and the Cre-LoxP system. Research focuses on elucidating the precise neurobiological mechanisms of drug addiction and the pathogenesis of Alzheimer’s disease while developing novel therapeutic strategies.

Includes study and work experience.

Education

2015.09–2019.06: Ph.D. in Neuropharmacology, Sichuan University

2004.09–2007.06: M.Sc. in Health Toxicology, Sun Yat-sen University

1999.09–2004.06: B.Sc. in Preventive Medicine, Sun Yat-sen University

Work Experience

2024.10–Present: AssociateProfessor, Shenzhen University of Advanced Technology(SUAT)

2021.09–Present: Associate Researcher, Shenzhen Institute of Advanced Technology (SIAT)

2019.07–2021.06: Deputy Chief Physician, Sichuan Provincial Center for Disease Control and Prevention

2007.10–2015.08: Physician / Chief Physician, Sichuan Provincial Center for Disease Control and Prevention

Selected publications

1.Xu W, Li H, Wang L, et al. Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice. Nature Communications. 2020 Nov 24;11(1):5962. (JCR Q1,CAS Q1)

2.Xu W, Zhang J, Li H, et al. Simvastatin blocks reinstatement of cocaine-induced conditioned place preference in mice with brain lipidome remodeling. Neuroscience Bulletin. 2021 Dec;37(12):1683-1702. ( JCR Q1,CAS Q2)

3.Xu YL, Zhu L, Chen ZJ, Deng XF, Liu PD, Li S, Lin BC, Yang CZ,Xu W(Co-corresponding author), Zhou KK, Zhu YJ. Release of Endogenous Brain-derived Neurotrophic Factor into the Lateral Entorhinal Cortex from the Paraventricular Thalamus Ameliorates Social Memory Deficits in a Mouse Model of Alzheimer's Disease. Neurosci Bull. 2022 Nov;38(11):1425-1430. (JCR Q1,CAS Q2)

4.Li H,Xu W(Co-first author), Wang D, et al. 4R Tau modulates cocaine-associated memory through adult hippocampal neurogenesis. Journal of Neuroscience. 2021 Aug 4;41(31):6753-6774. ( JCR Q1,CAS Q2)

5.Jiang C, Xu Y, Zhong J, Wu J, He J,Xu W(Co-corresponding author), Zhu Y. Chloral Hydrate Alters Brain Activation Induced by Methamphetamine-Associated Cue and Prevents Relapse. Front Mol Neurosci. 2022 Jul 11;15:934167. ( JCR Q2,CAS Q3)

6.Wang L, Wang X, Liu C,Xu W, Kuang W, Bu Q, Li H, Zhao Y, Jiang L, Chen Y, Qin F, Li S, Wei Q, Liu X, Liu B, Chen Y, Dai Y, Wang H, Tian J, Cao G, Zhao Y, Cen X. Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons. Genomics Proteomics Bioinformatics. 2023 Jun;21(3):551-572.( JCR Q1,CAS Q1)

7.Li HC, Zhang JM, Xu R, Wang YH,Xu W, et al. mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1-GluA2 interaction in the nucleus accumbens. Acta Pharmacol Sin. 2022 Feb;43(2):295-306. (JCR Q1,CAS Q1)