With a primary focus on aging and age-dependent diseases, the research employs modern biochemistry, molecular biology, and multi-omics to uncover the signaling pathways of aging and the commonalities and specificities of various age-related diseases such as cardiovascular diseases, diabetes, cancer, and neurodegenerative disorders. The goal is to develop blood biomarkers for aging and various neurodegenerative diseases, enabling precise treatment and early diagnosis of neurodegenerative conditions. This approach steadfastly adheres to the principle of driving the essential needs of the biotech industry through fundamental innovation.

Addressing the significant demands of the biotech industry and public health, this research integrates the concepts and methodologies of microbiology, immunology, physiology, neurobiology, and bioinformatics to explore microbial genetic resources and develop precise and efficient gene manipulation tools. These tools provide critical technical support for human microbiome engineering and cellular metabolic regulation. From a systems biology perspective, the research investigates the regulation of infection immunity, tumor immunity, and other physiological metabolic processes by the nervous system. It examines the interactions between microbes and the human body, elucidating the mechanisms by which microbes influence the onset and progression of diseases. By analyzing and integrating multidimensional omics information from a multimodal perspective, the research aims to offer targets and important theoretical support for disease prevention and intervention.

The construction of a stem cell biology research and transformation base, in collaboration with developmental biology, materials science, and basic medicine, focuses on breakthroughs in stem cell methodologies and technological development aimed at in vivo microecological regulation and tissue organ regeneration and replacement. This initiative is geared towards the comprehensive disciplinary development of therapeutic applications, enhancing the level of scientific and technological innovation, and establishing a national key stem cell transformation resource repository and core technology development platform.

With the etiology, mechanisms, symptoms, and treatment of tumors as the central focus of disciplinary development, the research emphasizes the exploration of cellular and molecular mechanisms underlying the onset and progression of major diseases such as cancer, and the establishment of specific and sensitive biomarkers and diagnostic criteria. Building on this foundation, the research employs structural biology, quantum computing, artificial intelligence, and other methods to identify efficient and low-toxicity drugs for key therapeutic targets, promoting the early diagnosis and optimal treatment of major diseases.

Leveraging the strengths of the major scientific and technological infrastructure for brain analysis and simulation, as well as the Guangming Brain Science and Technology Industrial Innovation Center, comprehensive research on brain function and brain diseases is conducted across multiple drugs, levels, and species. This includes the development and application of new technologies for brain function mapping, and the dissection of neural circuit mechanisms underlying higher brain functions such as perception, decision-making, and addiction, as well as the neural mechanisms of cognitive and emotional disorders throughout the lifespan. With cutting-edge achievements and advanced technologies, this research strongly supports the national key development plans of the Guangdong-Hong Kong-Macao Greater Bay Area, driving the rapid development of strategic emerging medical industries, intelligent industries, and mental health services.

Leveraging the strong interdisciplinary integration of biological sciences with physics, information science, and engineering, the research quantitatively analyzes the structure and function of biological systems to uncover the mechanisms of biological information processing and the fundamental principles of intelligence. Building on the cross-scale microscopic imaging technology that maps the subcellular structures and systemic connection architectures of biological entities, and combining this with the detection of optical, electrical, and chemical signals of cellular activities and the analysis of systemic behavioral functions, the research explores the learning principles of biological intelligence and new implementation methods for brain-inspired artificial intelligence. This drives the development of "New Engineering" and "New Medical" disciplines.