Dr. Qi Wan isaDistinguishedProfessorin theDepartment of Mental Health and Public Healthat Shenzhen University of Advanced Technology. He was aProfessor and Director in the Institute of Neuroregeneration and Neurorehabilitation at Qingdao University(2017-2024),the Executive Vice-Dean of Qingdao University School of Medicine (2017-2019), a Professor and Vice-Dean in the Medical School at Wuhan University (2013-2017), a tenured Associate Professor at University of Nevada at Reno (2008-2012) and a Scientist/Senior Scientist in the Toronto Western Research Institute (2000-2008). Hisresearchworkispublished in Nature, Nature Neuroscience, Nature Medicine, Stem Cells, Aging Cell, Journal of Neuroscience and Stroke. Dr. Wan is a scholar of Medical Research Council of Canada (MRC). His research has been supported by Canadian Institutes of Health Research (CIHR), National Institutes of Health (NIH, USA), Heart and Stroke Foundation of Canada (HSFC) and American Heart Association (AHA), National Natural Science Foundation of China and National Key R&D Program of China.

Dr. Wan’ research is focused on understanding the cellular and molecular mechanisms of neurological disorderssuch as ischemic stroke, and the role of endogenous neurogenesis in brain repair.

Includes study and work experience.

Education

11/1998–03/2000,Senior Centennial Postdoctoral Fellow of Medical Research Council of Canada,Division of Fundamental Neurobiology, Toronto Western Research Institute, University of Toronto, Toronto, Canada

12/1996–11/1998,Postdoctoral Fellow of Medical Research Council of Canada,Division of Neuroscience, Hospital for Sick Children University of Toronto, Toronto, Canada

01/19911/1996,PhD (Neuroscience),Department of Physiology, the University ofHong Kong (University of Toronto-UniversityofHongKongJoint PhDFellowshipaward)

09/1987–07/1990,MSc (Trauma Surgery),Research Institute of Surgery, Third Military Medical University, Chongqing, China

08/1979–07/1984,MD (Medicine),Faculty of Medicine, Third Military Medical University, Chongqing,China

WorkExperience

09/2024 -Distinguished Professor, Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology, Shenzhen, China08/2017 – 09/2024,Professor & Dean, Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, 308 Ningxia Street, Qingdao, China 26607105/2018 – 01/2019,Executive Vice Dean,School of Medicine, Qingdao University, 308 Ningxia Street, Qingdao, China 26607108/2017 – 05/2018,Vice Dean for Research & International Affairs,School of Medicine, Qingdao University, 308 Ningxia Street, Qingdao, China 26607106/2014 -11/2016,Associate Director, Medical Research Institute of Wuhan University, Wuhan University, 185 Donghu St. Wuhan, Hubei, China 43007105/2013 - 07/2017,Vice Dean for Research, Graduate Studies & International Affairs School of Medicine, Wuhan University, 185 Donghu St. Wuhan, Hubei, China 43007105/2013 – 07/2017,Professor, Department of Physiology,School of Medicine, Wuhan University, 185 Donghu St. Wuhan, Hubei, China 43007101/2013 –03/2008 – 05/2013,Associate Professor (Tenure),Department of Physiology and Cell Biology,School of Medicine, University of Nevada, Reno, USA04/2006 – 03/2008,Senior Scientist, Division of Fundamental Neurobiology, Toronto Western Research Institute (Krembil Research Institute), University of Toronto, Canada03/2000 – 03/2006,Scientist,Division of Fundamental Neurobiology,Toronto Western Research Institute (Krembil Research Institute), University of Toronto, Canada08/1990 – 12/1992,Research Fellow,Department of Surgery, Sunnybrook Medical Centre, University of Toronto, Toronto, Canada09/1984 – 08/1990,Principal Investigator,Research Institute of Surgery, Third Military Medical University, Chongqing, P. R. China

Selected publications

Wenjia Du, Huanhuan Chen, Ilona Gróf, Lucien Lemaitre, Alexandra Bocsik, Adrian Perdyan, Jakub Mieczkowski, Mária A. Deli, Tibor Hortobágyi, Qi Wan & Oleg O. Glebov. Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability. Molecular Psychiatry. 2024; DOI:10.1038/s40380-024-02626-1

Hui Wang, Wenlong Ma, Wenjie Hu, Xiaohua Li, Na Shen, Zhuo Li, Xiangyi Kong, Tao Lin, Jingchen Gao, Ting Zhu, Fengyuan Che, Juan Chen, Qi Wan*. Cathodal Bilateral Transcranial Direct-Current Stimulation Regulates Selenium to Confer Neuroprotection after Rat Cerebral Ischemia-Reperfusion Injury. The Journal of Physiology (London). 2024; DOI:10.1113/JP285806

Yu Cui, Zhaolong Zhang, Mengfei Lv, Zhongying Duan, Wenhao Liu, Jingchen Gao, Rui Xu, Qi Wan*. Chromatin target of protein arginine methyltransferases alleviates cerebral ischemia/reperfusion-induced injury by regulating RNA alternative splicing. iScience. 2023; doi.org/10.1016/

Jingchen Gao, Xiyuran Wang, Xiangyi Kong, Xujin Yao, Jinyang Ren, Shujun Chen, Na Shen, Zhuo Li, Yitian Wang, Ye Wei, Oleg Glebovb, Qi Wan*. Proline-loaded chitosan nanoparticles penetrate the blood-brain barrier to confer neuroprotection in mice cerebral ischemia injury. ACS Applied Polymer Materials. 2023 Octorber. DOI: 10.1021/acsapm.3c02034

Xiangyi Kong, Xujin Yao, Jinyang Ren, Jingchen Gao, Yu Cui, Jiangdong Sun, Xiangyu Xu, Wenjie Hu, Hui Wang, Huanting Li, Oleg O. Glebov, Fengyuan Che, Qi Wan*. tDCS regulates ASBT-3-OxoLCA-PLOD2-PTEN signaling pathway to confer neuroprotection following rat cerebral ischemia-reperfusion injury. Mol Neurobiol. 2023 July. DOI: 10.1007/s12035-023-03504-7.

Ruixue Lei, Shu Wang, Anchun Liu, Jing Cheng, Zhifeng Zhang, Jinyang Ren, Xujin Yao, Xiangyi Kong, Wenlong Ma, Fengyuan Che, Juan Chen, Qi Wan*. Bilateral transcranial direct-current stimulation promotes migration of subventricular zone-derived neuroblasts toward ischemic brain. FASEB BioAdvances. 2023 Jul; 5(7): 277–286. doi.org/10.1096/fba.2023-00017.

Lv W, Jiang J, Xu Y, Chen Z, Wang Z, Xing A, Zheng X, Qu T, Wan Q*. Re-Exploring the Inflammation-Related Core Genes and Modules in Cerebral Ischemia. Mol Neurobiol. 2023 Mar 3. doi: 10.1007/s12035-023-03275-1.

Xin Zhou, Rui Zhao, Mengfei Lv, Xiangyu Xu, Wenhao Liu, Xiaohua Li, Yunyi Gao, Zhiyuan Zhao, Zhaolong Zhang, Yuxuan Li , Rui Xu, Wan Q, Yu Cui. ACSL4 Promotes Microglia-Mediated Neuroinflammation by Regulating Lipid Metabolism and VGLL4 expression. Brain Behav Immun. 2023 Feb 13;S0889-1591(23)00037-5. doi: 10.1016/j.bbi.2023.02.012.

Juan Chen, Yang Zhuang, Ya Zhang, Huabao Liao, Rui Liu, Jing Cheng, Zhifeng Zhang, Jiangdong Sun, Jingchen Gao, Xiyuran Wang, Shujun Chen, Liang Zhang, Fengyuan Che, Wan Q*. A synthetic BBB-permeable tripeptide GCF confers neuroprotection by increasing glycine in the ischemic brain. Frontiers in Pharmacology. 15 August 2022; 18:249. 13:950376. doi: 10.3389/fphar.2022.950376.

Cui Y, Zhang Z, Zhou X, Zhao Z, Zhao R, Xu X, Kong X, Ren J, Yao X, Wen Q, Guo F, Gao S, Sun J, Wan Q*. Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression. Journal of Neuroinflammation 2021;18:249. doi: 10.1186/s12974-021-02231-x.

Cheng J, Fan YQ, Jiang HX, Chen SF, Chen J, Liao XY, Zou YY, Lan HY, Cui Y, Chen ZB, Chen QX，Wan Q*. Transcranial direct-current stimulation protects against cerebral ischemia- reperfusion injury through regulating Cezanne-dependent signaling. Experimental Neurology. July 27, 2021, doi.org/10.1016/j.expneurol.2021.113818.

Chen SF, Pan MX, Tang JC, Cheng J, Zhao D, Zhang Y, Liao HB, Liu R, Zhuang Y, Zhang ZF, Chen J, Lei RX, Li SF, Li HT, Wang ZF, Wan Q*. Arginine is neuroprotective through suppressing HIF-1α/LDHA-mediated inflammatory response after cerebral ischemia/reperfusion injury. Molecular Brain. 2020 Apr 22;13(1):63

Zhao D, Qin XP, Chen SF, Liao XY, Cheng J, Liu R, Lei Y, Zhang ZF, Wan Q*. PTEN inhibition Protects Against Experimental Intracerebral Hemorrhage-Induced Brain Injury through PTEN/E2F1/β-catenin pathway. Front. Mol. Neurosci. 2019; 12: 281

Liu R, Liao XY, Pan MX, Tang JC, Chen SF, Zhang Y, Lu PX, Lu LJ, Zou YY, Qin XP, Bu LH, Wan Q*. Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF-κB p65/Hif-1α Signaling Pathway. J Immunol. 2019;202(6):1704-1714

Zhang ZF, Chen J, Han X, Zhang Y, Liao HB, Lei RX, Zhuang Y, Wang ZF, Li Z, Chen JC, Liao WJ, Zhou HB, Liu F, Wan Q*. Bisperoxovandium (pyridin-2-squaramide) Targets Both PTEN and Erk1/2 to Confer Neuroprotection. British Journal of Pharmacology 2017; 174(8):641–656. doi: 10.1111/bph.13727

Li LJ, Hu R, Lujan B, Chen J, Zhang JJ, Nakano Y, Cui TY, Liao M, Chen JC, Man H, Feng H, Wan Q*. Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-containing NMDA Receptors. Frontiers in Molecular Neuroscience. 2016; 9:102.

Zheng M, Liao M, Cui T, Fan DS, and Wan Q*: Regulation of nuclear TDP-43 by NR2A-containing NMDA receptor and phosphatase PTEN. J Cell Science 2012; 125:1556-67

Hu R, Duan B, Wang D, Yu Y, Li W, Luo H, Lu P, Lin J, Zhu G, Wan Q and Feng H: Role of acid-sensing ion channel 1a in the secondary damage of traumatic spinal cord injury. Annals of Surgery 2011;254:1–10

Chang N, Li L, Hu R, Shan Y, Liu B, Li L, Wang H, Feng H, Wang D, Cheung CC, Liao M and Wan Q*: Differential regulation of NMDA receptor function by DJ-1 and PINK1. Aging Cell. 2010; 9:837–850

Cheung CC, Yang C, Berger T, Zaugg K, Reilly P, Elia AJ, Wakeham A, You-Ten A, Chang N, Li LJ, Wan Q, and Mak TW: Identification of BERP (brain-expressed Ring finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA-A receptors. Proc Natl Acad Sci USA. 2010; 107(26):11883-8

Liu B, Li L, Zhang Q, Chang N, Wang D, Shan Y, Li L, Wang H, Feng H, Zhang L, Brann DW and Wan Q*: Preservation of GABAA receptor function by PTEN inhibition protects against neuronal death in ischemic stroke. Stroke 2010; 41(5):1018-26

Li L, El-Hayek YH, Liu BS, Chen Y, Gomez E, Wu XH, Ning K, Li LJ, Chang C, Zhang L, Wang ZG, Hu X, Wan Q*: Direct-current Electrical Field Guides Neural Stem/progenitor Cell Migration. Stem Cells 2008; 26(7): 1610-1836

Li L and Wan Q*: rSac3, a new member of Sac domain phosphoinositide phosphatases family. Cell Research 2007; 17:1-3

Chang N, El-Hayek YH, Gomez E and Wan Q*: Phosphatase PTEN in neuronal injury and brain disorders. Trends in Neurosciences 2007; 30(11): 581-586

Liu B, Liao M, Mielke JG, Li L, Chen Y, Ning K, El-Hayek YH, Zukin RS, Fehlings MG, Wan Q*: Ischemic insults direct GluR2-lacking AMPA receptors to synaptic sites. Journal of Neuroscience, 2006; 26(20):5309-19

Ji SP, Zhang Y, Cleemput JV, Jiang W, Liao M, Li L, Wan Q, Backstrom JR & Zhang X: Disruption of protein-protein coupling between PTEN and serotonin 5- HT2C receptor suppresses marijuana rewarding effects. Nature Medicine 2006;12(3):324-9

Ning K, Li L, Liao M, Liu B, Mielke JG, Chen Y, Duan Y, El-Hayek YH, Wan Q*: Circadian regulation of GABA(A) receptor function by CKIepsilon-CKIdelta in the rat suprachiasmatic nuclei. Nature Neuroscience. 2004; 7(5):489-490

Ning K, Pei L, Liao M, Liu B, Zhang Y, Jiang W, Mielke JG, Li L, Chen Y, El- Hayek YH, Fehlings MG, Zhang X, Liu F, Eubanks J, Wan Q*: Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN. Journal of Neuroscience. 2004; 24(16):4052-60

Liu F, Wan Q, Pristupa ZB, Yu XM, Wang YT, Niznik HB: Direct protein-protein coupling enables cross-talk between dopamine D5 and γ-aminobutyric acid A receptors. Nature. 2000; 403:274-280

Wan Q, Man HY, Liu F, Braunton J, Niznik HB, Pang SF, Brown GM, Wang YT: Differential modulation of GABAA receptor function by MEL1a and MEL1b receptors. Nature Neuroscience. 1999; 2(5): 401-403

Wan Q, Xiong ZG, Man HY, Ackerley CA, Braunton J, Lu WY, Becker LE, MacDonald JF, Wang YT: Recruitment of functional GABAA receptors to postsynaptic domains by insulin. Nature. 1997; 388:686-690

Awards

Oct 2007,National Distinguished Youth Award,Natural Science Foundation of China

Jul 2000,Scholar,Heart and Stroke Foundation of Canada.This is a national Scholarship Award to faculties by Heart and Stroke Foundation of Canada.

May 2000,Scholar,Medical Research Council of Canada.This is a national Scholarship award to faculties by Medical Research Council of Canada.